Xu Y, Fleming S, Tegtmeyer M, McCarroll S, Babadi M., “Modeling interpretable correspondence between cell state and perturbation response with CellCap.” biorxiv, Mar 2024.

 

Anton Bolanos N*, Faravelli I*, Faits T, Andreadis S, Trattaro S, Kastli R, Adiconis X, Di Bella D,

Tegtmeyer M, Nehme R, Levin J, Regev A, Arlotta P., “Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers.” biorxiv, Oct 2023. (in press, Nature)

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Lakes Y, Move S, Mo J, Tegtmeyer M, Nehme R, Salinas G, McKay R, Eggan K, Charlton M, Le L.

,“Econazole selectively induces cell death in NF1-homozygous mutant tumor cells.” Cell Reports Medicine, Dec 19;4(12):101309. doi: 10.1016/j.xcrm.2023.101309

 

Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A,Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ,Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M,Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, PerlisR, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M,Eggan K., “The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.” NatureCommunications, Jun 27;13(1):3690. doi: 10.1038/s41467-022-31436-8

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Gazestani V, Kamath T, Nadaf NM, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Rauramaa T, Therrien M, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh S, Malm T, Hiltunen M, Nehme R, Stevens B, Leinonen V, Macosko EZ., “Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states.” Cell, Sep 28;186(20):4438-4453.e23. doi:

10.1016/j.cell.2023.08.005

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Tegtmeyer M*, Asgari S*, Arora J*, Cimini B, Peirent E, Liyanage D, Way G, Weisbart E, Nathan A, Amariuta T, Eggan K, Haghighi M, McCarroll S, Carpenter A, Singh S, Nehme R, Raychaudhuri S., “High-dimensional phenotyping to define the genetic basis of cellular morphology.” Nature Communications, Jan 6;15(1):347. doi: 10.1038/s41467-023-44045-w

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Berryer M*, Tegtmeyer M*, Binan L, Valakh V, Nathanson A, Trendafilova D, Crouse E, Klein J, Meyer D, Pietilainen O, Rapino F, Farhi S, Rubin L, McCarroll S, Nehme R, Barrett L., “Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells.” iScience, May 30;26(7):106995. doi: 10.1016/j.isci.2023.106995

 

Wells MF, Nemesh J, Ghosh S, Mitchell JM, Salick MR, Mello CJ, Meyer D, Pietilainen O, Piccioni F,

Guss EJ, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer KA, Ho D, Kommineni S, Chan K, Peterson BK, Raymond JJ, Gold JT, Siekmann MT, Zuccaro E, Nehme R, Kaykas A, Eggan K, McCarroll SA., “Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages.” Cell Stem Cell, Mar 2;30(3):312-332.e13. doi: 10.1016/j.stem.2023.01.010

 

Rapino F, Natoli T, Limone F, O’Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J,

Hazelbaker D, Angelini G, Barrett L, O’Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD,

Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL., “Small-molecule screen

reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.” Stem Cell Reports, Jan 10;18(1):237-253. doi: 10.1016/j.stemcr.2022.11.018

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Tegtmeyer M, Nehme R., “Leveraging the Genetic Diversity of Human Stem Cells in Therapeutic

Approaches.” Journal of Molecular Biology, Feb 15;434(3):167221. doi: 10.1016/j.jmb.2021.167221