The Tegtmeyer Lab
The Department of Biological Sciences
Purdue Institute for Integrative Neuroscience
Purdue Institute for Drug Discovery
Purdue University
West Lafayette, IN
We are a translational genomics lab dedicated to bridging the gap between genetic discoveries and biological functions of neuropsychiatric conditions. Our focus is on developing and applying genomic methods to study complex traits and polygenic diseases across diverse populations. We aim to identify disease-associated genes and pathways, enabling an understanding of their functional roles in specific cell types, ultimately seeking to discover and validate targets for new therapies.
Research
Interests
A major challenge in modern genetic medicine is the disparity between the simplicity of genetic testing and the limited availability of experimental platforms capable of delivering meaningful interpretations for the increasing number of novel and rare variants.
I am fascinated by the intricate genetic underpinnings of human diseases and traits. The exact biological mechanisms through which genetic variation influences complex traits and diseases are still largely unknown. My research aims to uncover these mechanisms by examining intermediate phenotypes, such as gene expression, cellular morphology and chromatin architecture. To facilitate this, I develop and implement novel experimental approaches which enable high-throughput characterization of these phenotypes. I am keenly interested in exploring the relationships between measurable phenotypes across a range of tissues and cellular models, as well as across diverse species.
- Matthew Tegtmeyer, Principal Investigator